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Dr. Glass’ Major pursuits are to understand transcriptional mechanisms that control the event and function of macrophages. Macrophages Engage in important roles in immunity, wound repair service, development and tissue homeostasis. Dysregulation of macrophage capabilities add to some wide spectrum of human diseases, which include atherosclerosis, diabetic issues, neurodegenerative diseases, and most cancers. A major energy on the Glass laboratory is to implement genomics assays and associated bioinformatics methods to understand how macrophage gene expression applications are established and how they are motivated by distinct tissue environments and sickness.
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Final Up to date: 04/05/2012 This project brings together bioinformatics and units biology to design experiments, assess superior-throughput/significantÂâ€material details (on DNA sequence, gene expression, proteinâ€DNA interactions and metabolomics), reconstruct network designs and establish new hypotheses within the molecular mechanisms of hypoxia susceptibility and tolerance in Drosophila, mouse and humans.
Mechanisms of signal-induced tumor chromosomal translocations functions and new chemical screens for inhibitors for breast and prostate most cancers.
These instruments are accustomed to defining the spatial distribution of normal products and solutions in 2D, 3D and in some instances serious-time. Regions of recent investigate directions are capturing mass spectrometry expertise to grasp the microbiome, non invasive drug metabolism checking, informatics of metabolomics, microbe-microbe, microbe-immune cells, microbe-host, stem mobile-most cancers cell interactions and diseased vs. non-illness model organisms and the event of procedures for mass spectrometry dependent genome mining also to detect and structurally characterize metabolites through group source annotation of molecular info on the worldwide All-natural Goods Social Molecular Networking internet site from the NIH supported Heart for computational mass spectrometry that is certainly co-formulated with Nuno Bandeira. A more in-depth biography can be found Within this Mother nature post.
Proteomics is the big-scale study of proteomes within a biological technique. Developing on innovations in mass spectrometry and info sciences, proteomics ways have made available powerful indicates in knowledge of cardiovascular disorders.
The opportunity to review expertise graphs (and, by extension, other networks of biomedical interactions) to recognize relationships supporting conclusions about heart problems. Pupils will likely acquire familiarity with the over at this website symptomology of heart problems.
Our lab applies our skills in human pluripotent stem cell investigate and genomics to be familiar with the molecular mechanisms underlying typical and irregular human progress, to be able to Increase the overall health of moms and toddlers.
Bioinformatics could be the study of a posh field that incorporates using Pc computer software and programming to help with a proper know-how and understanding of distinct principles or aspects of genomics including the identification of nucleotides In combination with genes.
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The new experimental innovations in one mobile biology have authorized us to know highly granular Organic information of disease at one cell resolution. In spite of the availability of a myriad of techniques to superior tease apart correct biological signals from technical sounds, there are actually numerous challenges in addressing complex Organic inquiries.
What's the "quick listing" of skills and competencies you seek out when employing persons for bioinformatics positions, Specifically entry-stage and intern positions?
Our lab is serious about the development of DNA methylation biomarkers for overall health and disorder. This features biomarkers for growing old from saliva and blood along with biomarkers for organ distinct disorders from plasma. We develop applications to investigate DNA methylation facts and acquire biomarkers making use of machine Understanding.
The laboratory’s research is focused on knowing the fundamental mechanisms controlling gene expression in mammalian cells. Particularly, the laboratory is investigating a few related complications: